SAFB Antibody

SAFB, HAP, HET, Scaffold attachment factor B, SAB-B1, SAFB1, SAF-B, SAF-B1, Scaffold attachment factor B1, Hsp27 ERE-TATA binding protein, HSP27 ERE-TATA-binding protein

WB: 1:500 - 1:2000

IF: 1:50 - 1:200

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human SAFB (NP_002958.2).

6294

scaffold attachment factor B

SAFB

Homo sapiens

Liquid

Affinity purification

Other

Q15424

Optimal dilutions for each application to be determined by the researcher.