HAMP Antibody

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ProSci
Product Code: PSI-16-373
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-16-373-50uL50uL£433.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of extracts of MDA-MB-435 cells, using HAMP antibody (16-373).<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.
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Western blot analysis of extracts of MDA-MB-435 cells, using HAMP antibody (16-373).<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.

Documents

Further Information

Additional Names:
putative liver tumor regressor, liver-expressed antimicrobial peptide, PLTR, LEAP1, LEAP-1, HFE2B, HEPCIDIN, HEPC, hepcidin antimicrobial peptide, HAMP, UNQ487/PRO1003
Application Note:
WB: 1:500 - 1:2000
Background:
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human HAMP (NP_066998.1).
NCBI Gene ID #:
57817
NCBI Official Name:
hepcidin antimicrobial peptide
NCBI Official Symbol:
HAMP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 10kDa
Purification:
Affinity purification
Research Area:
Immunology, Innate Immunity, Signal Transduction
Swissprot #:
P81172
User NOte:
Optimal dilutions for each application to be determined by the researcher.