DMP1 Antibody

DMP1, dentin matrix acidic phosphoprotein, dentin matrix protein 1, ARHP, ARHR, DMP-1

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DMP1 (NP_004398.1).

1758

dentin matrix acidic phosphoprotein 1

DMP1

Homo sapiens

Liquid

Affinity purification

Cell Cycle, Signal Transduction, Stem Cell

Q13316

Optimal dilutions for each application to be determined by the researcher.