KIR2DL1 Antibody
| Code | Size | Price |
|---|
| PSI-16-818-50uL | 50uL | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Documents
Further Information
Additional Names:
CD158A, KIR-K64, KIR221, KIR2DL3, NKAT, NKAT-1, NKAT1, p58.1, killer cell immunoglobulin-like receptor 2DL1, CD158 antigen-like family member A, KIR2DL protein, KIR2DL1/3DL2, MHC class I NK cell receptor, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, killer inhibitory receptor 2-2-1, natural killer-associated transcript 1, p58 NK cell inhibitory receptor NKR-K6, p58 NK receptor CL-42/47.11, p58 killer cell inhibitory receptor KIR-K64, p58 natural killer cell receptor clones CL-42/47.11, p58.1 MHC class-I-specific NK receptor
Application Note:
WB: 1:500 - 1:2000
Background:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human KIR2DL1 (XP_003403624.1).
NCBI Gene ID #:
3802
NCBI Official Name:
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
NCBI Official Symbol:
KIR2DL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 35kDa
Purification:
Affinity purification
Research Area:
Immunology
Swissprot #:
P43626
User NOte:
Optimal dilutions for each application to be determined by the researcher.