Further Information
ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2
WB: 1:500 - 1:2000
IHC: 1:100 - 1:200
IF: 1:50 - 1:200
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ACVR2A (NP_001607.1).
92
activin A receptor, type IIA
ACVR2A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 57kDa
Affinity purification
Cancer, Cell Cycle, Signal Transduction, Stem Cell
P27037
Optimal dilutions for each application to be determined by the researcher.
