CXCR2 Antibody
| Code | Size | Price |
|---|
| PSI-19-026-50uL | 50uL | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Documents
Further Information
Additional Names:
Cxcr2, mIL-8RH, interleukin-8 receptor type B, interleukin 8 receptor, beta, IL-8Rh, IL-8rb, Il8rb, IL8RA, IL-8R B, IL-8 receptor alpha chain, high affinity interleukin-8 receptor B, GRO/MGSA receptor, Gpcr16, CXC-R2, CXCR-2, C-X-C chemokine receptor type 2, Cmkar2, chemokine (C-X-C) receptor 2, chemokine (C-X-C motif) receptor 2, CDw128, CD128, IL8RB
Application Note:
WB: 1:500 - 1:2000
Background:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant protein of human CXCR2.
NCBI Gene ID #:
3579
NCBI Official Name:
chemokine (C-X-C motif) receptor 2
NCBI Official Symbol:
CXCR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 41kDa
Purification:
Affinity purification
Research Area:
Apoptosis, Cell Cycle, Immunology, Signal Transduction
Swissprot #:
P25025
User NOte:
Optimal dilutions for each application to be determined by the researcher.