NPC2 Antibody

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ProSci
Product Code: PSI-19-648
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-19-648-50uL50uL£433.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Shipping:
Blue Ice or RT
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western blot analysis of extracts of mouse lung, using NPC2 antibody (19-648) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 90s.
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Immunohistochemistry of paraffin-embedded human liver damage using NPC2 Antibody (19-648) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human esophagus using NPC2 Antibody (19-648) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse lung using NPC2 Antibody (19-648) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of mouse lung, using NPC2 antibody (19-648) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 90s.
Immunohistochemistry of paraffin-embedded human liver damage using NPC2 Antibody (19-648) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using NPC2 Antibody (19-648) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using NPC2 Antibody (19-648) at dilution of 1:100 (40x lens).

Documents

Further Information

Additional Names:
NPC2, tissue-specific secretory protein, NP-C2, Niemann-Pick disease, type C2, MGC1333, HE1, epididymal secretory protein E1, epididymal secretory protein, epididymal protein 1, EDDM1
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-151 of human NPC2 (NP_006423.1).
NCBI Gene ID #:
10577
NCBI Official Name:
Niemann-Pick disease, type C2
NCBI Official Symbol:
NPC2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 19kDa
Purification:
Affinity purification
Research Area:
Neuroscience, Signal Transduction
Swissprot #:
P61916
User NOte:
Optimal dilutions for each application to be determined by the researcher.