SKAP2 Antibody

SCAP2, src family associated phosphoprotein 2, MGC10411, MGC33304, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, Fyn-associated phosphoprotein SKAP55 homologue, Pyk2/RAFTK-associated protein, src kinase-associated phosphoprotein of 55-related protein, src-associated adaptor protein

WB: 1:500 - 1:2000

IHC: 1:50 - 1:100

IF: 1:50 - 1:100

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SKAP2 (NP_003921.2).

8935

src kinase associated phosphoprotein 2

SKAP2

Homo sapiens

Liquid

Observed: 50kDa

Affinity purification

Signal Transduction

O75563

Optimal dilutions for each application to be determined by the researcher.