GSTM3 Antibody

GSTM3, GST5, GSTB, GSTM3-3, GTM3, MGC3310, MGC3704

WB: 1:500 - 1:2000

IF: 1:50 - 1:200

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 101-225 of human GSTM3 (NP_000840.2).

2947

glutathione S-transferase mu 3 (brain)

GSTM3

Homo sapiens

Liquid

Observed: 25kDa

Affinity purification

Cancer, Signal Transduction

P21266

Optimal dilutions for each application to be determined by the researcher.