CTSC Antibody

CTSC, cathepsin C, CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I, OTTHUMP00000235623, OTTHUMP00000235624, OTTHUMP00000235625, OTTHUMP00000235627, cathepsin J, dipeptidyl peptidase 1, dipeptidyl peptidase I, dipeptidyl transferase, dipeptidyl-peptidase

WB: 1:500 - 1:2000

IHC: 1:50 - 1:100

This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805.3).

1075

cathepsin C

CTSC

Homo sapiens

Liquid

Observed: 70kDa

Affinity purification

Cell Cycle

P53634

Optimal dilutions for each application to be determined by the researcher.