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This product comes from:
Switzerland.
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Further Information
Alternate Names/Synonyms:
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13(5aH,12bH)-tetraone
Yellow to orange solid.
22200-69-7
32160000
liquid
Protect from light.Protect from light when in solution.
InChI=1S/C20H10O4S/c21-15-9-5-1-3-7-11(9)17(23)19-13(15)14-16(22)10-6-2-4-8-12(10)18(24)20(14)25-19/h1-8,13,19H
XYWAAJHFTBPXOA-UHFFFAOYSA-N
Chemical. CAS: 22200-69-7. Formula: C20H8O4S. MW: 344.3. Synthetic. Originally isolated from marine bacterium Serinicoccus sp. strain CNJ927. Seriniquinone is a potent cytotoxic and melanoma-selective anticancer agent. Upon cellular treatment and based on the compounds fluorescent nature it was found localized in the endoplasmic reticulum. Seriniquinone inhibits cell proliferation marked by autophagocytosis and induces cell death due to caspase-9 dependent apoptosis. Mode of action studies suggest that it specifically targets a skin protective antimicrobial peptide dermcidin (DCD), whose role as a cancer-protective protein has been recently recognized.
C20H8O4S
344.3
Plastic Vial
Seriniquinone is a potent cytotoxic and melanoma-selective anticancer agent. Upon cellular treatment and based on the compounds fluorescent nature it was found localized in the endoplasmic reticulum. Seriniquinone inhibits cell proliferation marked by autophagocytosis and induces cell death due to caspase-9 dependent apoptosis. Mode of action studies suggest that it specifically targets a skin protective antimicrobial peptide dermcidin (DCD), whose role as a cancer-protective protein has been recently recognized.
>99% (HPLC)
O=C1C(C(C2C3=O)C(C4=C3C=CC=C4)=O)=C(S2)C(C5=CC=CC=C51)=O
Soluble in DMSO (10mg/ml) or DMF (15mg/ml). Insoluble in water.
Synthetic. Originally isolated from marine bacterium Serinicoccus sp. strain CNJ927.
Non-hazardous
Natural Products/Extracts
12352200
Stable for at least 1 year after receipt when stored at -20°C.Stock solutions are stable for at least 3 months when stored at -20°C.