GABA [gamma-Aminobutyric acid]
| Code | Size | Price |
|---|
| AG-CR1-3664-G001 | 1 g | £28.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
4-Aminobutanoic acid; Piperidic acid; Piperidinic acid
Appearance:
White crystals or crystalline powder.
CAS:
56-12-2
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChiKey:
BTCSSZJGUNDROE-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 56-12-2. Formula: C4H9NO2. MW: 103.12. Amino acid that functions as the major inhibitory neurotransmitter in the mammalian central nervous system and also functions as a neuromodulator in some peripheral tissues. GABAA and GABAB receptor agonist that increases Cl- conductance. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation and anaesthetics. GABA can also influence heart rate and blood pressure and function as a immunomodulator. GABA signaling stimulates alpha-cell-mediated beta-like cell neogenesis. GABA induced insulin-producing beta-like cell neogenesis.
MDL:
MFCD00008226
Molecular Formula:
C4H9NO2
Molecular Weight:
103.12
Package Type:
Vial
Product Description:
Amino acid that functions as the major inhibitory neurotransmitter in the mammalian central nervous system and also functions as a neuromodulator in some peripheral tissues. GABAA and GABAB receptor agonist that increases Cl- conductance. GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action results in a negative change in the transmembrane potential, usually causing hyperpolarization. GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation and anaesthetics. GABA can also influence heart rate and blood pressure and function as a immunomodulator. GABA signaling stimulates alpha-cell-mediated beta-like cell neogenesis. GABA induced insulin-producing beta-like cell neogenesis.
Purity:
>98%
SMILES:
OC(CCCN)=O
Solubility Chemicals:
Soluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +20°C.
References
GABA (gamma-aminobutyric acid), a non-protein amino acid counters the beta-adrenergic cascade-activated oncogenic signaling in pancreatic cancer: a review of experimental evidence: H.A. Al-Wadei, et al.; Mol. Nutr. Food Res. 55, 1745 (2011) | GABA is an effective immunomodulatory molecule: Z. Jin, et al.; Amino Acids 45, 87 (2013) | Anion transport and GABA signaling: C.A. Huebner & K. Holthoff; Front. Cell Neurosci. 7, 177 (2013) (Review) | Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions: T. Crowley, et al.; Brain Behav. Immun. 54, 260 (2016) | Mechanisms and functions of GABA co-release: N.X. Tritsch, et al.; Nat. Rev. Neurosci. 17, 139 (2016) (Review) | The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling: R. Mazzoli & E. Pessione; Front. Microbiol. 7, 1934 (2016) (Review) | Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis: N. Ben-Othman, et al.; Cell 168, 73 (2017) | GABA Signaling Stimulates beta Cell Regeneration in Diabetic Mice: G.C. Weir & S. Bonner-Weir; Cell 168, 7 (2017)