L-Glutamine [H-Gln-OH]

(+)-Glutamine; Levoglutamide; (S)-2,5-Diamino-5-oxopentanoic acid; L-Glutamic acid 5-amide; NSC 27421

White to off-white powder.

56-85-9

32160000

liquid

Protect from light and moisture.

InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1

ZDXPYRJPNDTMRX-VKHMYHEASA-N

Chemical. CAS: 56-85-9. Formula: C5H10N2O3. MW: 146.1. L-Glutamine is an amino acid and is essential in the formation of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate and other amino acids as well as in protein synthesis and glucose production. It plays also a role in lipid synthesis (e.g. in cancer cells), cellular energy as a source next to glucose, nitrogen donation for many anabolic processes, including the synthesis of purines and carbon donation, as a source refilling the citric acid cycle. It is a nontoxic transporter of ammonia in the blood circulation and a precursor to the neurotransmitter glutamate and GABA. L-Glutamine is an essential amino acid which is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine exerts potent antioxidant and anti-inflammatory effects, next to its roles in cell proliferation and cancer. Levels of L-glutamine in human white adipose tissue (WAT) are linked with obesity-associated inflammation. Addition of L-glutamine in obese mice attenuated adipose tissue inflammation. Reduced L-glutamine levels during obesity shift the balance from glutaminolysis toward glycolysis, leading to nuclear O-GlcNAcylation, which activates inflammation.

MFCD00008044

C5H10N2O3

146.1

Note: L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. The rate at which degradation proceeds is a function of time, temperature and pH. If used as a cell culture supplement, a 200mM stock solution (29.2mg/ml L-glutamine in 0.85% NaCl) can be prepared. The optimal concentration is dependent upon the cell type and medium used to culture the cells, but generally falls in the range of 2-6mM.

Vial

L-Glutamine is an amino acid and is essential in the formation of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate and other amino acids as well as in protein synthesis and glucose production. It plays also a role in lipid synthesis (e.g. in cancer cells), cellular energy as a source next to glucose, nitrogen donation for many anabolic processes, including the synthesis of purines and carbon donation, as a source refilling the citric acid cycle. It is a nontoxic transporter of ammonia in the blood circulation and a precursor to the neurotransmitter glutamate and GABA. L-Glutamine is an essential amino acid which is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine exerts potent antioxidant and anti-inflammatory effects, next to its roles in cell proliferation and cancer. Levels of L-glutamine in human white adipose tissue (WAT) are linked with obesity-associated inflammation. Addition of L-glutamine in obese mice attenuated adipose tissue inflammation. Reduced L-glutamine levels during obesity shift the balance from glutaminolysis toward glycolysis, leading to nuclear O-GlcNAcylation, which activates inflammation.

>99% (TLC)

NC(CC[C@H](N)C(O)=O)=O

Soluble in water (30 mg/ml).

Non-hazardous

Biochemical Reagents

12352200

Stable for at least 2 years after receipt when stored at RT.