Tim-4 (mouse):Fc (human) (rec.)
| Code | Size | Price |
|---|
| AG-40B-0180-C050 | 50 ug | £210.00 |
Quantity:
| AG-40B-0180-3050 | 3 x 50 ug | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4
Biological Activity:
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Concentration:
1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Recombinant Proteins. The extracellular domain of mouse Tim-4 (aa 23-279) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Lyophilized. Contains PBS. Endotoxin levels: <0.01EU/µg purified protein (LAL test).. Tim-4 (T cell immunoglobulin and mucin domain-containing protein 4) is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. Tim-4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 is expressed solely on antigen presenting cells (APCs) and is not found on T cells in contrast to TIM1 and TIM3. Tim-4 has a short intracellular domain and lacks an inward signaling motif. Tim-4 plays an important role in the proliferation of T helper type 2 (Th2) cells. Tim-4 binds to phosphatidylserine (PS) on the surface of apoptotic cells in a calcium-dependent manner and mediates phagocytosis of apoptotic cells.
Molecular Weight:
~110kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q6U7R4
Package Type:
Plastic Vial
Product Description:
Tim-4 (T cell immunoglobulin and mucin domain-containing protein 4) is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. Tim-4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 is expressed solely on antigen presenting cells (APCs) and is not found on T cells in contrast to TIM1 and TIM3. Tim-4 has a short intracellular domain and lacks an inward signaling motif. Tim-4 plays an important role in the proliferation of T helper type 2 (Th2) cells. Tim-4 binds to phosphatidylserine (PS) on the surface of apoptotic cells in a calcium-dependent manner and mediates phagocytosis of apoptotic cells.
Purity:
>95% (SDS-PAGE)
Sequence:
The extracellular domain of mouse Tim-4 (aa 23-279) is fused to the N-terminus of the Fc region of human IgG1.
Source / Host:
HEK 293 cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.