anti-Calponin-1 Rabbit Monoclonal (RM262)

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RevMab Biosciences
Product Code: REV-31-1143-00
Product Group: Primary Antibodies
CodeSizePrice
REV-31-1143-00-R100100 ul£455.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM262
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Western Blot (WB)
Shipping:
Blue Ice
Storage:
+4°C

Images

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Immunocytochemistry of HeLa cells, using Calponin-1 Rabbit Monoclonal Antibody (Clone RM262) (red). Actin filaments have been labeled with fluorescein phalloidin (green), and nucleus stained with DAPI (blue).
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Immunocytochemistry of HeLa cells, using Calponin-1 Rabbit Monoclonal Antibody (Clone RM262) (red). Actin filaments have been labeled with fluorescein phalloidin (green), and nucleus stained with DAPI (blue).

Documents

Further Information

Alternate Names/Synonyms:
Calponin H1, Smooth Muscle
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the C-terminus of human Calponin-1.
Long Description:
Recombinant Antibody. This antibody reacts to human or mouse Calponin-1. Applications: WB, ICC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.
NCBI, Uniprot Number:
P51911
Package Type:
Vial
Product Description:
Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human or mouse Calponin-1.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.