anti-Vimentin (human) Rabbit Monoclonal (RM289)

N/A

32160000

liquid

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.

Avoid freeze/thaw cycles.

A peptide corresponding to the C-terminus of human Vimentin. .

Recombinant Antibody. This antibody reacts to human Vimentin. It may also react to mouse or rat Vimentin, as predicted by immunogen homology. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Vimentin is a developmentally regulated intermediate filament protein (IFP) found in mesenchymal cells. It is believed to be involved in the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria and subsequent transport of cholesterol to the organelles lead to an increase in steroid synthesis. Vimentin has been used as a sarcoma tumor marker to identify mesenchyme.

P08670

Vial

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in mesenchymal cells. It is believed to be involved in the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria and subsequent transport of cholesterol to the organelles lead to an increase in steroid synthesis. Vimentin has been used as a sarcoma tumor marker to identify mesenchyme.

Protein A purified.

Rabbit

This antibody reacts to human Vimentin. It may also react to mouse or rat Vimentin, as predicted by immunogen homology.

Non-hazardous

Primary Antibodies

12352203

Stable for at least 1 year after receipt when stored at -20°C.