anti-N6-Methyladenosine Rabbit Monoclonal (RM362)

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RevMab Biosciences
Product Code: REV-31-1248-00
Product Group: Primary Antibodies
CodeSizePrice
REV-31-1248-00-C05050 ug£457.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM362
Regulatory Status: RUO
Target Species: Universal
Applications:
  • Dot Blot
  • Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
Blue Ice
Storage:
+4°C

Images

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Dot blot of Lambda DNA without or with m6A, using anti-m6A antibody (RM362). The membrane was pre-spotted with 5, and 0.5 ng/dot of lambda DNA. m6A-free DNA was isolated from bacteriophage lambda grown in an E. coli host-deficient in adenine methylase (da
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Dot blot of Lambda DNA without or with m6A, using anti-m6A antibody (RM362). The membrane was pre-spotted with 5, and 0.5 ng/dot of lambda DNA. m6A-free DNA was isolated from bacteriophage lambda grown in an E. coli host-deficient in adenine methylase (da

Documents

Further Information

Alternate Names/Synonyms:
m6A
Concentration:
1 mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
BSA-conjugated N6-Methyladenosine.
Long Description:
Recombinant Antibody. This antibody reacts to N6-Methyladenosine (m6A) in both RNA and DNA. No cross reactivity with non-methylated adenosine. Applications: DotBlot, ELISA, MeRIP. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR.
NCBI, Uniprot Number:
N/A
Package Type:
Vial
Product Description:
N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to N6-Methyladenosine (m6A) in both RNA and DNA. No cross reactivity with non-methylated adenosine.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.