anti-MMP-12 (human) Rabbit Monoclonal (RM381)
| Code | Size | Price |
|---|
| REV-31-1267-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM381
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
MMP12; Matrix Metalloproteinase-12
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to C-terminus of human Matrix metalloproteinase-12 (MMP-12).
Long Description:
Recombinant Antibody. This antibody reacts to human Matrix metalloproteinase-12 (MMP-12). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Active MMP-12 (Macrophage metalloelastase; MME; Macrophage elastase; ME) has a broad substrate range. In addition to its activity against elastin, MMP-12 has been shown to cleave human CXC-chemokines such as CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8. It also degrades collagen type IV, fibronectin, laminin, vitronectin, and certain proteoglycans. Although it seems to be mainly involved in COPD, MMP-12 has also been reported to be involved in malignant progression in colorectal, nonsmall cell lung cancer, prostate cancer, hepatocarcinoma and head and neck squamous cell carcinomas. The protease MMP12 is also involved in macrophage migration and potentially could have a crucial role in regulating the resolution of inflammation, by cleaving IFNγ, thereby rendering the cytokine unable to signal via its receptor.
NCBI, Uniprot Number:
P39900
Package Type:
Vial
Product Description:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Active MMP-12 (Macrophage metalloelastase; MME; Macrophage elastase; ME) has a broad substrate range. In addition to its activity against elastin, MMP-12 has been shown to cleave human CXC-chemokines such as CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8. It also degrades collagen type IV, fibronectin, laminin, vitronectin, and certain proteoglycans. Although it seems to be mainly involved in COPD, MMP-12 has also been reported to be involved in malignant progression in colorectal, nonsmall cell lung cancer, prostate cancer, hepatocarcinoma and head and neck squamous cell carcinomas. The protease MMP12 is also involved in macrophage migration and potentially could have a crucial role in regulating the resolution of inflammation, by cleaving IFNgamma, thereby rendering the cytokine unable to signal via its receptor.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human Matrix metalloproteinase-12 (MMP-12).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.