anti-p38 MAPK (human) Rabbit Monoclonal (RM245)

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RevMab Biosciences
Product Code: REV-31-1126-00
Product Group: Primary Antibodies
CodeSizePrice
REV-31-1126-00-R100100 ul£455.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM245
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Blue Ice
Storage:
+4°C

Images

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Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-p38 MAPK RM245 at a 1:5000 dilution.
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Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-p38 MAPK RM245 at a 1:5000 dilution.

Documents

Further Information

Alternate Names/Synonyms:
Mitogen-activated Protein Kinase p38
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to human p38 MAPK.
Long Description:
Recombinant Antibody. This antibody reacts to human p38 MAPK. This antibody may also react to rat and mouse p38 MAPK, as predicted by immunogen homology. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. p38 MAP kinase (MAPK) participates in a signaling cascade controlling cellular responses to cytokines and stress. Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light and growth factors. MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF-2, Max and MEF2. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development.
NCBI, Uniprot Number:
Q16539
Package Type:
Vial
Product Description:
p38 MAP kinase (MAPK) participates in a signaling cascade controlling cellular responses to cytokines and stress. Four isoforms of p38 MAPK, p38alpha, beta, gamma (also known as Erk6 or SAPK3), and delta (also known as SAPK4) have been identified. p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light and growth factors. MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF-2, Max and MEF2. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human p38 MAPK. This antibody may also react to rat and mouse p38 MAPK, as predicted by immunogen homology.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.