anti-AMPK alpha-1 (human) Rabbit Monoclonal (RM301)
| Code | Size | Price |
|---|
| REV-31-1186-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM301
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
AMPKA1; 5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the residues near the C-terminus of human AMPK alpha-1.
Long Description:
Recombinant Antibody. This antibody reacts to human AMPK alpha-1 (AMPKA1) (5'-AMP-activated protein kinase catalytic subunit alpha-1). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK?s role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity and diabetes. 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha 1) belongs to the serine/threonine protein kinase family and is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK).
NCBI, Uniprot Number:
Q13131
Package Type:
Vial
Product Description:
AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK?s role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity and diabetes. 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha 1) belongs to the serine/threonine protein kinase family and is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK).
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human AMPK alpha-1 (AMPKA1) (5'-AMP-activated protein kinase catalytic subunit alpha-1).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.