anti-Aurora-B (human) Rabbit Monoclonal (RM278)
| Code | Size | Price |
|---|
| REV-31-1159-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM278
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
AURKB
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the N-terminus of human Aurora kinase B.
Long Description:
Recombinant Antibody. This antibody reacts to human Aurora kinase B. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.
NCBI, Uniprot Number:
Q96GD4
Package Type:
Vial
Product Description:
Aurora-B plays a critical role in cell division and chromosome-microtubule interactions during mitosis. Aurora-B kinase is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin and borealin, which determine the activity, localization, stability and possibly even the substrate specificity of Aurora-B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora-B. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-Aurora-B complex may be responsible for modifying histone H3. Aurora B phosphorylates Histone H3 at residues Serine 53 and Serine 28 during prophase, leading to the dissociation of HP1 from chromatin and condensation of chromosome. Aurora-B was found to be overexpressed in several malignant cancers and is involved in promoting tumor development and progression.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human Aurora kinase B.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.