SARS-CoV-2 (COVID-19) S1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-97-086-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Virus
Application: Western Blot (WB)
Storage:
Lyophilized protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Background References:
- Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.
- Benvenuto D, et al. J Med Virol. 2020.
- Chang CY, et al. AMB Express. 2020. 10(1):20.
Buffer:
Lyophilized from 0.22 um filtered solution in Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5. Normally trehalose is added as protectant before lyophilization.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
43740568
NCBI Official Name:
surface glycoprotein
NCBI Official Symbol:
S
NCBI Organism:
Severe acute respiratory syndrome coronavirus 2
Physical State:
Lyophilized
Predicted Molecular Weight:
101.5 kDa
Protein Accession #:
QHD43416.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells