Darunavir . ethanolate
| Code | Size | Price |
|---|
| PSI-10-022-50mg | 50mg | £409.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
TMC114; TMC41629; UIC-94017; HSDB 7788; Prezista
Background:
Darunavir ethanolate is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. The ethanolate formulation has some stability advantages compared to the free base Darunavir (Prod. No. AG-CR1-3712). Darunavir ethanolate is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain like viral protease (PLVP) of SARS-CoV-2, responsible for COVID-19.
CAS:
635728-49-3
Formula:
C27H37N3O7S . C2H5OH
Identity:
Determined by 1H-NMR.
InChi Key:
QWSHKNICRJHQCY-VBTXLZOXSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
547.7 . 46.0
Purity:
greater than or equal to 98% (HPLC)
Smiles:
NC1=CC=C(S(=O)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CO[C@]4([H])[C@@]3([H])CCO4)=O)CC(C)C)=O)C=C1.CCO
Solubility:
Soluble in DMSO (10mg/ml) or 100% ethanol (5mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (10mg/ml) or 100% ethanol (5mg/ml).