Mycophenolic acid
| Code | Size | Price |
|---|
| PSI-10-030-500mg | 500mg | £476.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
MPA; NSC 129185; Ly 68618; Mycophenolate
Background:
Antibiotic [1]. Shows antiviral, antifungal and antitumor properties [1, 2]. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis [3-6, 13]. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation [7, 8]. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform [11]. Inhibits RNA and DNA synthesis [13]. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor [8, 10]. Apoptosis and necrosis inducer [9, 12]. Novel type of inhibitor against RNA guanylyltransferases [14]. Inhibits TNF-α-stimulated MAPK/NF-κB and ROS generation [15]. Autophagy suppressor. Broad-spectrum antiviral compound with inhibitory activity against different coronavirus, including SARS-CoV, MERS-CoV and SARS-CoV-2, cause of COVID-19. It binds to the active site of SARS-CoV-2 papain-like protease (PLpro) possibly inhibiting viral replication.
CAS:
24280-93-1
Formula:
C17H20O6
InChi Key:
HPNSFSBZBAHARI-RUDMXATFSA-N
Merck Index:
4.977083333
Physical State:
Lyophilized
Predicted Molecular Weight:
320.3
Purity:
greater than or equal to 98% (HPLC, TLC)
Rtecs:
MP8050000
Smiles:
COC1=C(C)C2=C(C(=O)OC2)C(O)=C1CC=C(/C)CCC(O)=O
Solubility:
Soluble in DMSO (25mg/ml) or water (25mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (25mg/ml) or water (25mg/ml).
Source/Host Chemicals:
Isolated from Penicillium brevi-compactum.