Ruxolitinib (free base)
| Code | Size | Price |
|---|
| PSI-10-042-25mg | 25mg | £360.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
INCB018424; INC 424
Background:
Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19).
CAS:
941678-49-5
Formula:
C17H18N6
Identity:
Determined by 1H-NMR and MS.
InChi Key:
HFNKQEVNSGCOJV-OAHLLOKOSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
306.4
Purity:
greater than or equal to 98% (HPLC)
Smiles:
N#CC[C@H](C1CCCC1)N1C=C(C=N1)C1=NC=NC2=C1C=CN2
Solubility:
Soluble in DMSO (>100mg/ml) and water (8mg/ml). Slightly soluble in 100% ethanol.
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (>100mg/ml) and water (8mg/ml). Slightly soluble in 100% ethanol.