Ruxolitinib . phosphate salt
| Code | Size | Price |
|---|
| PSI-10-043-25mg | 25mg | £336.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
INCB018424; INC 424
Background:
Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)
CAS:
1092939-17-7
Formula:
C17H18N6 . H3O4P
Identity:
Determined by 1H-NMR and MS.
InChi Key:
JFMWPOCYMYGEDM-XFULWGLBSA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
306.4 . 98.0
Purity:
greater than or equal to 98% (HPLC)
Smiles:
N#CC[C@H](C1CCCC1)N(N=C2)C=C2C3=NC=NC4=C3C=CN4.OP(O)(O)=O
Solubility:
Soluble in DMSO (10mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in DMSO (10mg/ml).