Tofacitinib . citrate
| Code | Size | Price |
|---|
| PSI-10-047-100mg | 100mg | £409.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
blue ice
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture and oxygen. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
CP-690550; Xeljanz; Tasocitinib
Background:
Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19). PRK1 inhibitor.
CAS:
540737-29-9
Formula:
C16H20N6O . C6H8O7
Identity:
Determined by 1H-NMR.
InChi Key:
SYIKUFDOYJFGBQ-YLAFAASESA-N
Physical State:
Lyophilized
Predicted Molecular Weight:
312.4 . 192.1
Purity:
greater than or equal to 98% (HPLC)
Smiles:
OC(CC(O)=O)(CC(O)=O)C(O)=O.O=C(CC#N)N1C[C@@H]([C@H](C)CC1)N(C)C2=NC=NC3=C2C=CN3
Solubility:
Soluble in ethanol (10mg/ml), DMSO (15mg/ml) or DMF (20mg/ml).
Soluble In Dmf, Ethanol, Dmso Or Aqueous Solvents (Pbs).:
Soluble in ethanol (10mg/ml), DMSO (15mg/ml) or DMF (20mg/ml).