anti-FOXP3 (mouse) mAb (MF333F)
| Code | Size | Price |
|---|
| AG-20A-0025Y-C050 | 50 ug | £184.00 |
Quantity:
| AG-20A-0025Y-C100 | 100 ug | £260.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Rat IgG2akappa
Antibody Clonality: Monoclonal
Antibody Clone: MF333F
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
BLUE ICE
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Forkhead Box Protein P3; Scurfin
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant mouse FOXP3.
Long Description:
Monoclonal Antibody. Recognizes mouse FOXP3. Detects a band of ~46-49kDa by Western blot. Isotype: Rat IgG2akappa. Clone: MF333F. Applications: ELISA, ICC, IHC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.
NCBI, Uniprot Number:
Q99JB6
Package Type:
Plastic Vial
Product Description:
FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes mouse FOXP3. Detects a band of ~46-49kDa by Western blot.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Alternatively activated dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig: Y.Y. Lan, et al.; J. Immunol. 177, 5868 (2006) | Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice: M.J. Perone, et al.; J. Immunol. 177, 5278 (2006) | Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance: E. Ambrosino, et al.; Cancer Res. 66, 7734 (2006) | Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells: G. Raimondi, et al.; J. Immunol. 176, 2808 (2006) | Antimetastatic activity of a preventive cancer vaccine: P. Nanni, et al.; Cancer Res. 67, 11037 (2007) | Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance: H.R. Turnquist, et al.; J. Immunol. 178, 7018 (2007) | Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells: F. Casiraghi, et al.; J. Immunol. 181, 3933 (2008) | Suppression of autoimmune diabetes by soluble galectin-1: M.J. Perone, et al.; J. Immunol. 182, 2641 (2009) | Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen: C. Hayashi, et al.; J. Immunol. 189, 3681 (2012) | Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice: Y. Yamada, et al.; Diabetologia 55, 2238 (2012)