anti-GBP1 (human) pAb (IN111)
| Code | Size | Price |
|---|
| AG-25B-6001-C050 | 50 ug | £160.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
BLUE ICE
Storage:
Short Term: +4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
Guanylate-binding Protein 1; GTP-binding Protein 1; Guanine Nucleotide-binding Protein 1; Interferon-induced Guanylate-binding Protein 1
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.05% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human GBP1 protein (aa 200-592).
Long Description:
Polyclonal antibody. Recognizes endogenous human GBP1. Application: WB. Source: Rabbit. Liquid. In PBS containing 0.05% sodium azide. Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.
NCBI, Uniprot Number:
P32455
Package Type:
Plastic Vial
Product Description:
Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.
Purity:
>95% (SDS-PAGE)
Source / Host:
Rabbit
Specificity:
Recognizes endogenous human GBP1.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.