Pepstatin A methyl ester
| Code | Size | Price |
|---|
| AG-CP3-7004-M001 | 1 mg | £80.00 |
Quantity:
| AG-CP3-7004-M005 | 5 mg | £290.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short Term: +4°C, Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
PME; Pepstatin A-OMe; Procidin S 735M; Pepsin Inhibitor S 735M
Appearance:
White to off-white powder.
CAS:
29169-91-3
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C35H65N5O9/c1-18(2)13-24(38-34(47)32(22(9)10)40-35(48)31(21(7)8)39-28(43)15-20(5)6)26(41)16-29(44)36-23(11)33(46)37-25(14-19(3)4)27(42)17-30(45)49-12/h18-27,31-32,41-42H,13-17H2,1-12H3,(H,36,44)(H,37,46)(H,38,47)(H,39,43)(H,40,48)/t23-,24-,25-,26-,27-,31-,32-/m0/s1
InChiKey:
QDSKCDUNZOMSAY-XAFAIMEYSA-N
Long Description:
Chemical. CAS: 29169-91-3. Formula: C35H65N5O9. MW: 699.9. Cell permeable methyl ester derivative of Pepstatin A. Potent, non-competitive, transition-state analog inhibitor of gamma-secretase.
Molecular Formula:
C35H65N5O9
Molecular Weight:
699.9
Package Type:
Vial
Product Description:
Cell permeable methyl ester derivative of Pepstatin A. Potent, non-competitive, transition-state analog inhibitor of gamma-secretase.
Purity:
>95% (HPLC)
SMILES:
O[C@@H](CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(OC)=O)=O)=O)[C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CC(C)C)=O)=O)=O
Solubility Chemicals:
Soluble in DMSO (5mg/ml).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Interaction of human cathepsin D with the inhibitor pepstatin: C.G. Knight & A.J. Barret; Biochem. J. 155, 117 (1976) | Linear Non-competitive Inhibition of Solubilized Human gamma-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines: G. Tian, et al.; J. Biol. Chem. 277, 31499 (2002) | The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors: G. Tian, et al.; J. Biol. Chem. 278, 28968 (2003)