Siglec-10 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-190-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Cynomolgus Monkey
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Background:
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Background References:
- Whitney G.,?et al.?2001, Eur J Biochem., 268(23), 6083-96.
- Kivi E.,?et al.?2009, Blood., 114(26), 5385-92.
- Munday J.,?et al.?2001, Biochem J., 355(Pt 2), 489-97.
Buffer:
25 mM MES, 150 mM NaCl, pH5.5
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
60.2 kDa
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells