B7-H6 / NCR3LG1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-451-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Cynomolgus Monkey
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
B7-H6,NCR3LG1,B7 Homolog 6
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome.
Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Background References:
- Wu MR, et all., 2015, Gene Ther. 22(8):675-84.
- Phillips M, et all., 2016, Biopolymers. 106(5):658-72.
- Flajnik MF, et all., 2012 Immunogenetics. 64(8):571-90.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
102121659
NCBI Official Name:
natural killer cell cytotoxicity receptor 3 ligand 1
NCBI Official Symbol:
NCR3LG1
NCBI Organism:
Macaca fascicularis
Physical State:
Lyophilized
Predicted Molecular Weight:
28.4 kDa
Protein Accession #:
XP_005578557.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells