WNT-7A Recombinant Protein
| Code | Size | Price |
|---|
| PSI-40-577-0.003mg | 0.003mg | £300.00 |
Quantity:
| PSI-40-577-0.015mg | 0.015mg | £428.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Shipping:
blue ice or RT
Storage:
The lyophilized WNT-7A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted WNT-7A stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing WNT-7A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Documents
Further Information
Additional Names:
Protein Wnt-7a
Background:
Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions.
Biological Activity:
Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25 ng/ml of Murine Wnt-3a.
NCBI Gene ID #:
7476
NCBI Official Name:
wingless-type MMTV integration site family, member 7A
NCBI Official Symbol:
WNT7A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_004616.2
Protein GI Number:
17505191
Purity:
Greater than 80% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O00755