PLAU / uPA Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-306-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
Urokinase,PLAU,ATF,UPA,URK,u-PA,BDPLT5,QPD
Application Note:
This protein carries a polyhistidine tag at the C-terminus.
The active form of Human PLAU is a disulfide-linked heterodimer composed of long chain A (Ser 21 - Phe 177) and chain B (Ile 179 - Leu 431) with calculated MW of 17.8 kDa and 29.2 kDa. The long
Background:
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys ? Pro ? Gly - Arg560 - Val561 ? Val ? Gly ? Gly ? Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
Background References:
- Nagai M., et al., 1985, Gene 36:183.
- Jacobs P., et al., 1985, DNA 4:139.
- Harbeck, N. et al., 2002, Clin. Breast Cancer 3:196.
Buffer:
25 mM HEPES, 150 mM NaCl, pH7.5
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
15.3 kDa, 17.8 kDa and 29.2 kDa
Protein Accession #:
NP_002649.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells