ASGR1 / ASGPR1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-154-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1
Application Note:
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.8 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.
Background References:
- Bon C. et al., MAbs. 2017 Nov; 9(8): 1360?1369.
- Tanowitz M. et al., Nucleic Acids Res. 2017 Dec 1; 45(21): 12388?12400.
- Shi B. et al., J Histochem Cytochem. 2013 Dec; 61(12): 901?909.
Buffer:
PBS, pH7.4
Fusion Tag:
Fc Tag
NCBI Gene ID #:
432
NCBI Official Name:
asialoglycoproteinreceptor1
NCBI Official Symbol:
ASGR1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
52.8 kDa
Protein Accession #:
NP_001662.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P07306