SIRP beta / CD172b Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-452-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD172b antigen,CD172b,DKFZp686A05192,FLJ26614,SIRP beta 1,SIRPB1,SIRP-BETA-1,9930027N05Rik,SIRP-beta
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.7 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRPβ1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRPβ1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRPβ1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.
Background References:
- Gaikwad S.,?et al.?2009, Am J Pathol., 175(6), 2528-39.
- Dietrich J.,?et al.?2000, J Immunol., 164(1), 9-12.
- Tomasello E.,?et al.?2000, Eur J Immunol., 30(8), 2147-56.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
10326
NCBI Official Name:
signal regulatory protein beta 1
NCBI Official Symbol:
SIRPB1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
63.7 kDa
Protein Accession #:
NP_006056.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q5TFQ8