Complement Factor D / CFD Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-377-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CFD,Adipsin,PFD,DF,Complement factor D
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 28 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Background:
Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
Background References:
- White R.T., et al., 1992, J. Biol. Chem. 267:9210-9213.
- Johnson D.M.A., et al., 1984, FEBS Lett. 166:347-351.
- Sprong T., et al., 2006, Blood 107:4865-4870.
Buffer:
50 mM Tris, 150 mM NaCl, pH8.0
Fusion Tag:
His Tag
NCBI Gene ID #:
1675
NCBI Official Name:
complement factor D
NCBI Official Symbol:
CFD
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
26.3 kDa
Protein Accession #:
NP_001919.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P00746