IL-23 R Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-428-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IL-23 R,IL-23 Receptor
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.9 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Background References:
- Parham C., et al., 2002, J. Immunol. 168:5699-5708.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
149233
NCBI Official Name:
interleukin 23 receptor
NCBI Official Symbol:
IL23R
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
39.9 kDa
Protein Accession #:
NP_653302.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q5VWK5