PLGF / PGF (19-221) Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-159-0.02mg | 0.02mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PGF,PLGF,PlGF,PGFL,SHGC-10760
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Background References:
- Maglione D., et al., 1993, Oncogene 8 (4): 925?31.
- Khalil A., et al., 2008, PLoS ONE 3 (7): e2766.
- Khurana R., et al., 2005, Circulation 111 (21): 2828?2836.
- Rolny C., et al., 2011, Cancer Cell 19:31-44.
Buffer:
PBS, pH7.4
Fusion Tag:
Fc Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
49.2 kDa
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells