GITR Ligand / TNFSF18 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-399-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
TNFSF18,AITRL,TL6,hGITRL,GITR Ligand
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.5 kDa. The protein migrates as 23 kDa and 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
Background References:
- Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
- Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
20.5 kDa
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells