CD40 / TNFRSF5 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-496-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50
Application Note:
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 46.1 kDa. The protein migrates as 58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines.
Background References:
- Banchereau, J. et al., 1994, Annu. Rev. Immunol. 12: 881-922.
- Ni, C.Z. et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97: 10395-10399.
- Ferrari.S. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 12614-12619.
- Bhushan, A and Covey, L.R. 2001, Immunol. Res. 24: 311-324.
Buffer:
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
958
NCBI Official Name:
CD40 molecule
NCBI Official Symbol:
CD40
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
46.1 kDa
Protein Accession #:
NP_001241.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P25942