IL-8 / CXCL8 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-219-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 34.8 kDa. The protein migrates as 37-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Background References:
- Hedges JC. 2000. Am J Respir Cell Mol Biol. 23:86-94.
- Van Damme J. 1990. Eur J Immunol. 20(9):2113-8.
- H?bert CA. 1990. J Immunol. 145(9):3033-40.
Buffer:
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
3576
NCBI Official Name:
C-X-Cmotifchemokineligand8
NCBI Official Symbol:
CXCL8
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
34.8 kDa
Protein Accession #:
NP_000575.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P10145