CD209 / DC-SIGN Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-250-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
DC-SIGN,CD209,DC-SIGN1,CLEC4L
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
Background References:
- Geijtenbeek TB, et al. 2000. Nat Immunol. 1(4):353-7.
- Geijtenbeek TB, et al. 2000. Cell. 100(5):587-97.
- Engering A, et al. 2002. J Immunol. 168(5):2118-26.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
30835
NCBI Official Name:
CD209molecule
NCBI Official Symbol:
CD209
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
41.3 kDa
Protein Accession #:
NP_066978.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9NNX6