EphA4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-257-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
EphA4,HEK8,SEK,TYRO1,EK8
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.3 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Background References:
- Fu WY, et al. 2007. Nat Neurosci. 10:67-76.
- Miao H, et al. 2009. Cancer Cell. 16(1):9-20.
- Zhang G, et al. 2008. Cancer Res. 68(6):1691-6.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2043
NCBI Official Name:
EPHreceptorA4
NCBI Official Symbol:
EPHA4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
60.3 kDa
Protein Accession #:
NP_004429.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P54764