ErbB3 / Her3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-381-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
Background References:
- Singer, E. etal., 2001, J. Biol. Chem. 276 (47): 44266?74
- Kraus,M.H.etal.,1989,Proc.Natl.Acad.Sci.86:9193-9197.
- Carraway,K.L.etal.,1994,J.Biol.Chem.269:14303-14306.
- Wallasch,C.etal.,1995,EMBO.J.14:4267-4275.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2065
NCBI Official Name:
erb-b2 receptor tyrosine kinase 3
NCBI Official Symbol:
ERBB3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
70.5 kDa
Protein Accession #:
NP_001973.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P21860