IL-21 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-420-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IL21,Za11,Interleukin-21
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.9 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Background References:
- Chtanova T, et al., 2004, J Immunol 173 : 68?78.
- Wei L, et al., 2007, J Biol Chem 282 (48): 34605?10.
- Wurster AL, et al., 2002, J Exp Med 196 (7): 969?77.
- Iannello A, et al., 2010, J Leukoc Biol 87 (5): 857?67.
Buffer:
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
59067
NCBI Official Name:
interleukin 21
NCBI Official Symbol:
IL21
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
41.9 kDa
Protein Accession #:
NP_068575.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9HBE4