IL-4 R alpha / CD124 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-393-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IL4R,CD124,IL4RA
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
IL-4 R alpha is also known as IL4R, CD124, IL-4RA.This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Interleukin-4 receptor has been shown to interact with SHC1.
Background References:
- Tundup S., 2012, Ann. N. Y. Acad. Sci., 1253: E1?E13.
- Ikizawa K, Yanagihara Y., 2000, Biochem. Biophys. Res. Commun., 268 (1): 54?9.
- Kashiwada M., 2001, J. Immunol., 167 (11): 6382?7.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
3566
NCBI Official Name:
interleukin 4 receptor
NCBI Official Symbol:
IL4R
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
50.4 kDa
Protein Accession #:
NP_000409.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P24394