LAIR1 / CD305 Recombinant Protein

Product Code: PSI-11-537

Supplier: ProSci

Code	Size	Price

PSI-11-537-0.1mg

0.1mg

£729.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Human

Regulatory Status: RUO

Target Species: Human

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Western Blot (WB)

Shipping:

blue ice or RT

Storage:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

Documents

Datasheet

Further Information

Additional Names:

LAIR1,CD305

Application Note:

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Background:

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell?mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

Background References:

Pioli C, et all., 2000, J Immunol. 15;165(10):5530-6.
Brondijk TH, et all., 2010, Blood. 18;115(7):1364-73
Meyaard L, et all., 1997, Immunity. Aug;7(2):283-90.

Buffer:

Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5

Fusion Tag:

Fc Tag

NCBI Gene ID #:

3903

NCBI Official Name:

leukocyte associated immunoglobulin like receptor 1

NCBI Official Symbol:

LAIR1

NCBI Organism:

Homo sapiens

Physical State:

Lyophilized

Predicted Molecular Weight:

42.1 kDa

Protein Accession #:

AAH27899.1

Purity:

>95% as determined by SDS-PAGE.

Recombinant Protein Sequence:

#N/A

Source:

HEK293 cells

Swissprot #:

Q6GTX8