MICA Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-199-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
MIC-A
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 59.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Background:
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
Background References:
- Groh V., et al., 1998, Science 279:1737-1740.
- Bauer S., et al., 1999, Science 285:727-729.
- Steinle A., et al., 2001, Immunogenetics 53:279-287.
Buffer:
PBS, pH7.4
Fusion Tag:
Fc Tag
NCBI Gene ID #:
100507436
NCBI Official Name:
MHCclassIpolypeptide-relatedsequenceA
NCBI Official Symbol:
MICA
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
59.3 kDa
Protein Accession #:
AAH16929.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q29983