TNFSF11 / RANKL / CD254 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-11-157-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
blue ice or RT
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
RANKL,CD254,TRANCE,OPGL,ODF
Application Note:
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 47.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
Background References:
- Hanada R., et al., 2011, J. Mol. Med. 89 (7): 647-656.
- Findlay DM., et al., 2011, Osteoporos Int. 22 (10): 2597-2602.
- Schmiedel BJ., et al., 2013, Cancer Res. 73 (2): 683-694.
- Castellano D., et al., 2011, Oncologist. 16 (2): 136-145.
Buffer:
PBS, pH7.4
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
8600
NCBI Official Name:
TNFsuperfamilymember11
NCBI Official Symbol:
TNFSF11
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
47.4 kDa
Protein Accession #:
AAC51762.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O14788